Found 33 matching trials
Real-life Follow-up of Cystic Fibrosis Patients Treated With Ivacaftor+Lumacaftor (Orkambi*) N/A The purpose of the study is to examine the real-life safety and effectivene...
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Adult CF center, Service de Pneumologie, Cochin Hospital
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Lumacaftor/Ivacaftor Combination Therapy in Subjects With CF Who Have an A455E CFTR Mutation PHASE2 This is a Phase 2, randomized, double-blind, placebo-controlled, multicente...
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University Medical Center, Utrecht, Department of Pulmonology and Tuberculosis
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A Study of Lumacaftor in Combination With Ivacaftor in Cystic Fibrosis Subjects Aged 12 Years and Older Who Are Homozygous for the F508del-CFTR Mutation PHASE3 The primary objective of the study was to evaluate the efficacy of lumacaft...
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Multiple Locations
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Phase 1, QT/QTC Interval Study in Healthy Subjects PHASE1 This study is designed to evaluate the effect of multiple doses of lumacaft...
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Multiple Locations
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A Study to Evaluate the Safety and Efficacy of VX-371 in Subjects With Cystic Fibrosis Who Are Homozygous for the F508del-CFTR Mutation PHASE2 The purpose of this study is to evaluate the safety and efficacy of treatme...
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Multiple Locations
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Study to Evaluate Lumacaftor and Ivacaftor Combination Therapy in Subjects 12 Years and Older With Advanced Lung Disease PHASE3 The purpose of this study is to evaluate the safety and tolerability of LUM...
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Multiple Locations
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A Study to Evaluate the Efficacy and Safety of Lumacaftor in Combination With Ivacaftor in Subjects With CF, Homozygous for the F508del-CFTR Mutation PHASE3 To evaluate the efficacy and safety of lumacaftor in combination with ivaca...
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Multiple Locations
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Effect of Lumacaftor-ivacaftor on Glucose Handling and Tolerance in Cystic Fibrosis Phe508del NA The purpose of this research study is to find out if the combined therapy l...
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Multiple Locations
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Response to CFTR Modulators in CF Patients Under 18 Years N/A CFTR modulators should improve the prognosis of Cystic Fibrosis. Identifyin...
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Sermet-Gaudelus Isabelle
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A Study to Explore the Impact of Lumacaftor/Ivacaftor on Disease Progression in Subjects Aged 2 Through 5 Years With Cystic Fibrosis, Homozygous for F508del PHASE2 This study will explore the impact of lumacaftor/ivacaftor (LUM/IVA) on dis...
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Charite Paediatric Pulmonology Department
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